Due to increased adipose tissue, the effects of insulin at the tissue level change as a result of the release of adipokines originating from visceral, cutaneous and perivascular adipose tissue at different levels.
Insulin resistance has an important role in microvascular damage. The disease begins in a non-proliferative phase, progresses to a proliferative phase when uncontrolled diabetes is not treated, and results in significant eyesight loss.ĭiabetic retinopathy is a classic example of microvasculopathy triggered by hyperglycemia.ĭysfunction, death and insufficient renewal in endothelial and vascular smooth muscle cells, capillary endothelial cells and pericytes induced by hyperglycemia have a role in the pathogenesis of diabetic microvasculopathy.
Diabetic microvascular complications are related to the severity and duration of hyperglycemia. Diabetic retinopathy is the most common complications of diabetes and the major cause of visual loss in working-age adults. Diabetes and its complications are caused by a disruption in the physiological balance of the molecules that regulate glucose metabolism. These findings suggest that Alarin and Adipsin may play important role in diabetic retinopathy.ĭiabetes mellitus (DM) is a chronic condition characterized by hyperglycemia and caused by insulin insufficiency or resistance. Adipsin levels were found to be significantly higher in plasma in the control group than in the DR + C group and significantly higher in aqueous in the DR + C group than in the control group ( p < 0.001, p < 0.001).
Resultsīoth plasma and aqueous Alarin levels were significantly higher in the patients with diabetic retinopathy than in the control group ( p < 0.001, p = 0.006). Alarin and Adipsin levels were examined with the enzyme-linked immunosorbent assay (ELISA) method. Plasma and aqueous humour samples were taken from all patients during the cataract operation. The study included one eye from each of 20 cataract patients without diabetes (C), 20 cataract patients with diabetes and without diabetic retinopathy (DM + C), and 20 cataract patients with diabetes and diabetic retinopathy (DR + C). The aim of this study was to determine plasma and aqueous levels of Alarin and Adipsin in patients with and without diabetic retinopathy to evaluate their potential roles in diabetic retinopathy. Alarin and Adipsin are molecules with a role in energy and glucose metabolism. Diabetic retinopathy is a disease seen with microvascular complications as a result of hyperglycemia and insulin resistance.
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